System composition and characteristics

automatic control system

A chromatographic workstation based on advanced DCS distributed control strategy is developed to achieve control and data acquisition of pumps, valves, and various online detectors. It can easily complete multi column series and parallel operations, ensuring the stability and accuracy of the process.

Special online detection system for traditional Chinese medicine

Including the detection of conventional process parameters such as flow rate, pressure, temperature, pH value (optional), conductivity (optional), and real-time detection of the content of effective parts (or components) of traditional Chinese medicine using ultraviolet spectroscopy (optional) and near-infrared spectroscopy (optional).

Column structure of chromatography

The design of the chromatography column structure is excellent, with a reasonable aspect ratio, precise inlet and outlet fluid distribution devices, equipped with an automatic loading system and compressed air interface, ensuring the column loading effect and packing regeneration effect, providing a guarantee for efficient separation.

Application of chromatographic separation technology in the separation and purification of natural products

The chromatographic separation techniques commonly used in the separation and purification of traditional Chinese medicine include adsorption chromatography and ion exchange chromatography. Adsorption chromatography includes reverse phase chromatography technology (C18 reverse phase packing) and normal phase silica gel chromatography technology; Ion exchange chromatography is mainly used for the separation and purification of sub charged compounds. At present, chromatographic separation technology plays an increasingly important role in the refinement of effective ingredients in traditional Chinese medicine, such as flavonoids, alkaloids, glycosides, organic acids, and polysaccharides.

This unit is specifically designed and developed for the industrial scale purification of target compounds in the pharmaceutical industry. This preparation of liquid chromatography column has extremely high sample loading capacity, which provides a reliable guarantee for increasing the preparation amount of purified products at a lower cost.

Functional Features

Widely used in the extraction and refining of proteins, enzymes, monosaccharides, polysaccharides, and plant active ingredients. The characteristics of chromatographic separation are: mild operating conditions (room temperature, generally atmospheric pressure); Multiple pure components can be obtained simultaneously by passing the mixture through once; Can be precisely separated to obtain high-purity products. This unit incorporates modern computer automation control technology and online detection technology for process parameters, upgrading and transforming traditional manual chromatography equipment to improve its reliability. The equipment is easy to scale up the layering process and solves industrial production problems.

Application of natural product separation and purification

Development of small-scale processes, scaling up of pilot processes, preparation of plant chemical standards and control samples, etc. Widely used for separating pure products such as phenols, aldehydes, alkaloids, amino acids, steroids, mushrooms, flavonoids, quinones, organic acids, glycosides, sugars, nucleosides, etc. For example, paclitaxel, tea polyphenols, ginkgo flavonoids, bamboo leaf flavonoids, vitamin E, etc.